§ 113 “The only exceptions to this are the narcotic medicines. As they, in their primary action, take away sometimes the sensibility and sensation, sometimes the irritability, it frequently happens that in their secondary action , even from moderate experimental doses on healthy bodies, an increased sensibility (and a greater irritability) is observable.”
Explanation
§ 113 explains that narcotic medicines deviate from the usual pattern described in the previous aphorism. While most medicines follow a predictable pattern of action, narcotic medicines behave differently. In their initial action, they often reduce sensitivity or sensation, or sometimes even irritability. However, in their secondary action, which occurs after the initial effects have subsided, even moderate doses of narcotic medicines can lead to heightened sensitivity and increased irritability in healthy individuals.
